Carlotta Figliola

Chargée de recherche

Research Institute: Institut de Chimie et Procédés pour l'Énergie, l'Environnement et la Santé (ICPEES), UMR CNRS 7515

Research group: Groupe Chimie Organique pour les Matériaux et la Biologie (COMBO)

figliola@unistra.fr

Bâtiment R3, Niv2

Keywords: photodynamic therapy, imaging, boron complexes, labelling

Research topics

• Organic chemistry
• Medicinal chemistry
• Chemical reactions: mechanisms, dynamics, kinetics and catalytic reactions
• Spectroscopic techniques
• Electrochemistry, sensors

Research experience and education

• 2020-2021: Postdoctoral Fellow at CEA Saclay (Laboratoire de Marquage au ¹⁴C) on “Development of isotopic exchange methodologies for ¹⁴C-labelling of drug candidates” with Dr. Davide Audisio;
• 2018-2019: Postdoctoral Fellow at ENS Lyon (Functional Materials and Photonics group) on “Synthesis of photosensitizer-nanoscintillator conjugates for deep tissue penetration photodynamic therapy” with Dr. Frédéric Chaput;
• 2017-2018: Postdoctoral Fellow at iSm2 Marseille (STéRéO group) on “Diastereoselective boron functionalization, towards the synthesis of chiral cyclic NHC-diborene and boryl species” with Dr. Jean-Luc Parrain, Dr. Olivier Chuzel and Dr. Gaëlle Chouraqui;
• 2015-2017: Postdoctoral Fellow at Dalhousie University (Thompson group) on “Synthesis of prodigiosene bioconjugates for anticancer and photodynamic therapy; synthesis of dipyrrin and BODIPYs; development of pyrroles new reactivity” with Alison Thompson;
• 2010-2014: Ph.D. at the University of Birmingham on ʺ[Fe-Fe]-Hydrogenase synthetic mimics based on peri-substituted dichalcogenidesʺ with Dr. Richard S. Grainger;
• 2005-2010: Bachelor and Master Degree in Pharmaceutical Chemistry and Technologies at Università di Parma, Italy.

Selected publications

• “A step-wise synthetic approach is necessary to access γ-conjugates of folate: folate-conjugated prodigiosenes”, Figliola, C.; Marchal, E.; Groves, B. R.; Thompson, A. RSC Adv.  2019, 9, 14078-14092.
  
  
• “Photo-induced anticancer activity and singlet oxygen production of prodigiosenes”, Savoie, H.; Figliola, C.; Marchal, E.; Crabbe, B. W.; Hallett-Tapley, G. L.; Boyle, R. W.; Thompson, A. Photochem. Photobiol. Sci. 2018, 17, 599-606.

• “ Asymmetric Dipyrrin and F-BODIPYs Conjugated to Terminal Alkynes and Alkenes”, Figliola, C.; Robertson, K. N.; Greening, S.; Thompson, A. J. Org. Chem. 2017, 82, 7059-7064.

• “Prodigiosenes conjugated to tamoxifen and estradiol”, Marchal, E.; Figliola, C.; Thompson, A. Org. Biomol. Chem. 2017, 21, 5410-5427.

• “Synthesis and Anticancer Activity of Prodigiosenes bearing C-Ring Esters and Amides”, Lund, K. A. R.; Figliola, C.; Kajetanowicz, A.; Thompson, A. RSC Adv. 2017, 7, 18617-18627.